Sindhu Saji Jacob, MD

Sindhu Saji Jacob, MD

Associate Professor, Orthopaedic Surgery and Neurology 
Division of Neuro Rehabilitation
Program Medical Director, Brain Injury Rehabilitation, The Rehabilitation Institute of St. Louis

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(314) 362-4503

Dr. Jacob's clinical interests focus on Acquired Brain Injury including traumatic, non-traumatic and Brain Tumor Rehabilitation, as well as spasticity management. Dr. Jacob also has a strong interest in medical student and resident education. Dr. Jacob currently serves as the Medical Director for the Joint Commission accredited inpatient Brain Injury Rehabilitation program at the Rehabilitation Institute of St. Louis.

Common Diagnoses Treated

  • Moderate to severe traumatic brain injury rehab
  • Concussions and mild traumatic brain injury rehab
  • Brain tumor rehab
  • Anoxic brain injury rehab
  • Spasticity
  • Stroke rehab

Common Procedures

  • Botox therapy
  • Intrathecal baclofen (ITB) management

Clinical Office Locations

Hospital Affiliations

  • Barnes-Jewish Hospital
  • The Rehabilitation Institute of St. Louis

Academic Office Mailing Address

  • Washington University School of Medicine

    Campus Box 8518

    4444 Forest Park Avenue

    Saint Louis, MO 63108

Research Interests 

Dr. Jacob's research interests surround acquired brain injury recovery and rehabilitation as well as spasticity. 


Dr. Jacob earned a medical degree from Kottayam Medical College at Mahatma Gandhi University in Kerala, India. She worked as a Palliative Care Physician in the Republic of Ireland before migrating to US. She then completed a residency in physical medicine and rehabilitation at Washington University School of Medicine in St. Louis, Missouri, and joined as clinical teaching faculty with the Physical Medicine and Rehabilitation Residency Program in 2009. In the past, she has served as the Vice President of the Medical Executive Committee at the Rehabilitation Institute of St. Louis.

Board Certifications

  • Board-certified, American Board of Physical Medicine and Rehabilitation 
  • Brain Injury Medicine, American Board of Physical Medicine and Rehabilitation

Medical Degree

  • Kottayam Medical College, Mahatma Gandhi University, Kerala, India


  • Physical Medicine and Rehabilitation, Washington University School of Medicine, St. Louis, MO

Honors and Awards

  • Invited Lecture: Brain Repair & Neuroplasticity. 15th Annual Conference: Brain Injury Association of Missouri; October 4, 2019.
  • Attending of the Year Award 2013
  • Best Resident Seminar 2005 (PM&R Residency Program, Washington University in St. Louis)

Professional Societies and Organizations

  • American Academy of Physical Medicine and Rehabilitation
  • American Congress of Rehabilitative Medicine
  • Brain Injury Association of Missouri

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