David Clever, MD, PhD

Dr. Clever cares for patients with benign and malignant bone, muscle and connective tissue tumors. He has a particular interest in treating bone and soft tissue sarcoma and skeletal metastasis.

A cancer diagnosis can be life-altering and overwhelming. Dr. Clever takes pride in building strong relationships with his patients and collaborating with them to develop personalized and comprehensive treatment plans, and prepare for life after cancer treatment. Dr. Clever is always available for his patients, and is never more than a phone call or email away.

Common Diagnoses Treated

Avascular malformations
Bone cysts
Bone, muscle and connective tissue tumors
Bone pain
Chordoma
Enchondroma
Fibrous dysplasia
Heterotopic ossification
Imaging abnormalities
Leukemia bone disease
Lymphoma of the bone
Melanoma
Metabolic bone disease
Metastatic bone cancer
Multiple myeloma
Myositis ossificans
Nerve tumors
Osteochondroma
Osteoid osteoma
Paget’s disease
Pathologic fracture
Renal osteodystrophy
Sarcoma (soft tissue sarcoma, bone sarcoma, osteosarcoma, Ewing’s sarcoma, chondrosarcoma)
Second opinions
Vascular tumors

Common Procedures

Bone biopsy
Bone tumor resection
Displaced fracture treatment
Pathologic fracture management
Limb salvage surgery, including endoprosthesis, joint fusion, bone grafting, amputation, rotationplasty, custom joint replacements
Soft tissue biopsy
Muscle tumor resection
Preventative fracture treatment due to metastatic cancer
Revision hip and knee replacements (for previous failed, infected or painful hip and knee replacements)

Clinical Office Locations

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Academic Office Mailing Address

Washington University School of Medicine

Campus Box 8233

660 Euclid Avenue

Saint Louis, MO 63110

Patient Education

Musculoskeletal Oncology patient education

Patient Resources

Patient Forms

Click here for patient forms.

For a complete list of Dr. Clever's publications, visit PubMed.

Hong, Z, Clever D, Tatman L, Miller AN. “The effect of social deprivation on fracture healing and patient-reported outcomes following intramedullary nailing of tibial shaft fractures.” J Bone Joint Surg Am. 2022 Nov 16; 104 (22): 1968-1976.
Capietto AH, Lee S, Clever D, Eul E, Ellis H, Ma C, Faccio R. “Effective treatment of established bone metastases can be achieved by combinatorial osteoclast blockade and depletion of granulocytic subsets.” Cancer Immunology Research. Cancer Immunol Res. 2021 Dec: 9 (12): 1400-1412.
Obey M, Clever D, Bechtold D, McAndrew CM, Berkes MB, Miller AN. “In-Hospital Morbidiity and Mortality with Delays to Femoral Shaft Fracture Fixation.” Journal of Orthop Trauma. 2022 May 1; 36 (5): 239-245.
Clever D, Thompson D, Gosselin M, Brouillet K, Guilak F, Luhmann SJ. “Pilot Study Analysis of Serum Cytokines to Differentiate Pediatric Septic Arthritis and Transient Synovitis.” Journal of Pediatric Orthopaedics. 2021 Nov-Dec 01; 41 (10): 610-616.
Klebanoff CA, Crompton JG, Leonardi AJ, Yamamoto TN, Chandran SS, Eil RL, Sukumar M, Vodnala SK, Hu J, Ji Y, Clever D, Black MA, Gurusamy D, Kruhlak MJ, Jin P, Stroncek DF, Gattinoni L, Feldman SA, Restifo NP. “Inhibition of AKT signalling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.” JCI Insight. 2017 Dec 7; 2(23).
Gurusamy D*, Clever D*, Eil R*, Restifo N. “Novel Elements of Immune Suppression within the
Tumor Microenvironment.” Cancer Immunol Res. 2017 Jun; 5(6): 426-433. (Cover Article)
Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Klebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP. “T cell oxygen sensing establishes an immunologically tolerant metastatic niche.” Cell. 2016 Aug 25; 166: 1-15.
Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP. “Ionic immune suppression within the tumor microenvironment limits T cell effector function.” Nature. 2016 Sep 14;537(7621):539-543.
Roychoudhuri R*, Clever D*, Li P, Wakabayashi Y, Quinn KM, Ji Y, Klebanoff CA, Sukumar M, Yu Z, Eil RP, Spolski R, Palmer DC, Pan JH, Macallan DC, Fabozzi G, Kanno Y, Muto A, Zhu J, Gattinoni L, Igarashi K, O’Shea JJ, Leonard WJ, Restifo NP. “BACH2 regulates CD8+ T cell differentiation by modulating the availability of enhancers to signal-dependent transcription factors.” Nature Immunology. 09 May 2016; 17: 851-860.
Roychoudhuri R*, Eil RL*, Clever D*, Klebanoff CA, Sukumar M, Grant FM, Yu Z, Mehta G, Liu H, Jin P, Ji Y, Palmer DC, Pan JH, Chichura A, Crompton JG, Patel SJ, Stroncek D, Wang E, Marincola FM, Okkenhaug K, Gattinoni L, Restifo NP. “The transcription factor BACH2 mediates tumor immunosuppression.” The Journal of Clinical Investigation. 2016 Feb 1; 126(2):599-604.

Research Interests

Dr. Clever's research interests include sarcoma, tumor immunology and metastasis.

Background

Dr. Clever earned a medical degree from Ohio State University in Columbus, OH. He obtained a residency in orthopaedic surgery at Washington University in St. Louis, MO, then completed a fellowship in musculoskeletal oncology at the University of Toronto/Mount Sinai Hospital in Toronto, ON, Canada.

Medical Degree

Ohio State University in Columbus, OH

Residency

Orthopaedic Surgery, Washington University, St. Louis, MO

Fellowship

Musculoskeletal Oncology, University of Toronto/Mount Sinai Hospital in Toronto, ON, Canada

Professional Societies and Organizations

Connective Tissue Oncology Society
Musculoskeletal Tumor Society

Washington University Orthopedics