Regis O'Keefe, MD, PhD

Regis O'Keefe, MD, PhD

Chair, Department of Orthopaedic Surgery

Fred C. Reynolds Professor of Orthopaedic Surgery

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(314) 514-3500

Dr. O'Keefe is the Chair of the Department of Orthopaedic Surgery at Washington University School of Medicine. He is a an orthopaedic surgeon specializing in musculoskeletal oncology and adult reconstructive surgery of the hip and knee. He has clinical interests in the management of benign and malignant bone and soft (connective) tissue tumors in both children and adults, bone infections, skeletal reconstruction, curettage of bone tumors and allograft procedures, and primary and revision total hip and total knee arthroplasty.

Dr. O'Keefe received his medical degree from Harvard Medical School in 1985 and completed a surgical internship from Harvard Medical School/New England Deaconess Hospital in 1986. He served as an Instructor/Fellow of Research at the University of Rochester, School of Medicine and Dentistry until 1988, where he then went on to complete an orthopaedic surgery residency at the University of Rochester Medical Center in 1992. He then completed a Fellowship in Orthopaedic Oncology from the Massachusetts General Hospital in 1993. In 2000, he pursued a doctorate degree in biochemistry and biophysics from the University of Rochester, School of Medicine and Dentistry. 

Prior to arriving at Washington University School of Medicine, Dr. O'Keefe served as the Marjorie Strong Wehle Professor and the Chair of the Department of Orthopaedics and Rehabilitation at the University of Rochester School of Medicine and Dentistry in Rochester, NY. Dr. O'Keefe serves on the scientific committee of the J. Robert Gladden Orthopaedic Society, and on the mentoring committee of the Ruth Jackson Orthopaedic Society. Dr. O'Keefe is a member of the American Academy of Orthopaedic Surgeons, American Association for the Advancement of Science, American Board of Orthopaedic Surgeons, American Orthopaedic Association, American Society of Bone and Mineral Research, Association of American Physicians, Association of Osteobiology, Musculoskeletal Tumor Society, Orthopaedic Research Society and Siteman Cancer Center.

Common Diagnoses Treated

  • Soft tissue sarcomas
  • Benign soft tissue tumors
  • Osteosarcoma
  • Ewing Sarcoma
  • Chondrosarcoma
  • Benign bone tumors and cysts

Common Procedures

  • Excision of benign and malignant soft tissue tumors in both adults and children
  • Wide resections of bone tumors with reconstructive surgery
  • Curettage of bone tumors
  • Allograft procedures and treatment of bone infections
  • Total hip and revision total hip arthroplasty
  • Total knee and revision total knee arthroplasty

Clinical Office Location

  • Center for Advanced Medicine (CAM)

    Barnes Jewish Hospital

    4921 Parkview Place

    St Louis, MO 63110

Hospital Affiliations

  • Barnes-Jewish Hospital
  • Shriners Hospital for Children
  • St. Louis Children's Hospital
  • St. Louis Veterans Administration Medical Center, John Cochran Division

Academic Office Mailing Address

  • Washington University School of Medicine

    Campus Box 8233

    660 Euclid Avenue

    Saint Louis, MO 63110

National Leadership Positions

  • NIH Musculoskeletal Tissue Engineering Study Section Permanent Member, July 2016-2022
  • Search Committee for NIH Director of NIAMS 2019
  • Mentoring Committee, Ruth Jackson Orthopaedic Society, 2019-2022
  • Scientific Committee, J. Robert Gladden Orthopaedic Society, 2019-
  • President, American Orthopaedic Association (AOA), 2017
  • Director, American Board of Orthopaedic Surgery (ABOS), 2008-2017
  • National Institutes of Health (NIH) Council of Councils (CoC) Advisory Committee, 2010-2013
  • National Institutes of Health (NIH) National Arthritis and Musculoskeletal and Skin Disease Advisory Council, 2010-2013
  • Secretary, Orthopaedic Research Education Foundation, 2007-2011
  • Board of Trustees, Orthopaedic Research Education Foundation, 2003-2011
  • President, Orthopaedic Research Society, 2009-2010
  • Chair, Written Examination Committee, American Board of Orthopaedic Surgery, 2009-2012
  • Treasurer, Orthopaedic Research Society, 2004-2007
  • NIH Skeletal Biology and Skeletal Regeneration Study Section, Chair, National Institutes of Health Review Panel, 2004-2005
  • President, United States Bone and Joint Decade, 2003-2005
  • Dean’s Endowed Chair, Professor of Orthopaedics and Oncology, University of Rochester School of Medicine, 2000
  • Dean’s Endowed Chair, Associate Professor of Orthopaedics, University of Rochester School of Medicine, 1998

Honors and Awards

  • Alpha Omega Alpha (AOA) Honor Medical Society, Washington University in St. Louis School of Medicine Chapter. Induction March, 2019.
  • Alfred R. Shands Jr., MD, Award, Orthopaedic Research Society (ORS), 2019
  •  Orthopaedic Research Society and the Orthopaedic Research and Education Foundation 2013 Distinguished Investigator Award. Received on March 16, 2014. 
  • Fifth Annual Dr. Marvin J. Hoffman Award in the Area of Faculty Mentoring to Medical Students, Annual Hoffman Awards Ceremony, 2003
  • American Orthopaedic Association ABC Traveling Fellowship, 1999
  • The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and Educational Foundation, 1997
  • Kappa Delta Award, Orthopaedic Research and Education Foundation, 1995
  • AOA Resident Traveling Research Award, “Differential expression of transforming growth factor-ß receptors and biological effects in maturationally distinct subpopulations of growth plate chondrocytes.”, 1988

This is a partial listing of over 300 publications. For a complete listing, please visit this site.

  1. Zhang, X, Schwarz, EM, Young, DA, Xing, L, Boyce, BF, Puzas, JE, Rosier, RN, and O’Keefe, RJ: Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. The Journal of Clinical Investigation 109 (11):1405-1415, 2002
  2. Li, TF, Chen, D, Wu, Q, Sheu, T, Schwarz, EM, Drissi, H, Zuscik, MJ. and O’Keefe, RJ: TGF-beta Stimulates Cyclin D1 Expression through activation of beta-catenin signaling in chondrocytes. The Journal of Biological Chemistry 281 (30):21,296-304, 2006
  3. Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. The Journal of Clinical Investigation 118: 429-38, 2008
  4. Chen M, Zhu M, Awad H, Li TF; Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of (beta)-catenin signaling causes defects in postnatal cartilage development. Journal of Cell Science 21; (Pt 9):1455-65, 2008
  5. Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg, R, Drissi H, Puzas JE, Boyce B, Zhang X, O’Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fractured healing. The Journal of Bone and Mineral Research 24 (2): 251-64, 2009
  6. Tsutsumi R, Xie, C, Wei X, Zhang X, Flick LM, Schwarz EM, O’Keefe RJ. PGE2 signaling through the EP4 Receptor on fibroblasts upregulates RANKL and stimulates osteolysis. The Journal of Bone and Mineral Research 24 (10): 1753-62, 2009
  7. Gunnell, LM, Jonason, JH, Loiselle, AE, Kohn, A, Schwarz, EM, Hilton, M J. O'Keefe, RJ. TAK1 regulates cartilage and joint Development via the MAPK and BMP Signaling pathways. The Journal of Bone and Mineral Research 25 (8): 1784-97, 2010
  8. Li TF, Gao L, Sheu RJ, Sampson ER, Flick LM, Konttinnen YR, Chen D. Schwarz EM, Zuscik MJ, Jonason JH, O’Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis and Rheumatism 62 (8):2359-69, 2010
  9. Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O’Keefe RJ. EP1-/- mice have enhanced osteoblast differentiation and accelerated fracture repair. Journal of Bone and Mineral Research 26:792-802, 2011
  10. Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilage-specific ß-CATENIN signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development". Journal of Bone and Mineral Research 27:1680-1694, 2012
  11. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O’Keefe RJ. “BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway”. Osteoarthritis Cartilage 22(3): 481-9, 2014
  12. Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. “Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment”.  Bone. 62:79-89, 2014
  13. Hadjiargyrou M, O’Keefe RJ. “The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease”. Journal of Bone and Mineral Research 29(11):2307, 2014
  14. Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O’Keefe RJ. “Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair”. Journal of Orthopaedic Research 33:17, 2015
  15. Zhang M, Feigenson, M, Sheu, T-J, Awad, HA, Schwarz EM, Jonason JH, Loisell AE, O’Keefe RJ. “Loss of the PGE2 Receptor EP1 Enhances Bone Acquisition, Which Protects Against Age and Ovariectomy-induced Impairments in Bone Strength”. Bone 72:92-100, 2015
  16. O’Keefe RJ. “Fibrinolysis as a Target to Enhance Fracture Healing.” N Engl J Med 373(18):1776-8, 2015 
  17. Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O’Keefe RJ.  DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.  JCI Insight 2(12)e93612, 2017
  18. Dy CJ, Osei DA, Maak TG, Gottschalk MB, Zhang AL, Maloney MD, Presson AP, O’Keefe RJ. Safety of overlapping inpatient orthopaedic surgery: A multicenter study. J Bone Joint Surg 100(22): 1902-1911, 2018

Research Interests

Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone.

Clinical Interests

Management of benign and malignant bone and soft (connective) tissue tumors in both children and adults, bone infections, skeletal reconstruction, curettage of bone tumors and allograft procedures, and primary and revision total hip and total knee arthroplasty.

Medical Degree

  • Harvard Medical School

Residency

  • Orthopaedic Surgery, University of Rochester Medical Center

Fellowship

  • Orthopaedic Oncology, Massachusetts General Hospital

Doctorate Degree

  • Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry
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Dr. O'Keefe’s Office Location

Center for Advanced Medicine (CAM)

Barnes Jewish Hospital

4921 Parkview Place

St Louis, MO 63110

Disclaimer

The Department of Orthopaedic Surgery at Washington University School of Medicine in St. Louis has no control over third-party websites and does not review such websites. The university disclaims any responsibility for the content of third-party websites and the use of any information on these sites.

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