Fanxin Long, PhD

Fanxin Long, PhD
Professor of Medicine and Developmental Biology

Selected Publications

Fanxin Long, Xiaoyan M. Zhang, Seth Karp, Yingzi Yang and Andrew P. McMahon (2001). Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099-5108.
Fanxin Long, Ung-il Chung, Shinsuke Ohba, Jill McMahon, Henry M. Kronenberg and Andrew P. McMahon (2004). Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton.  Development 131, 1309-18.

Hongliang Hu, Matthew J. Hilton, Xiaolin Tu, Kai Yu, David M. Ornitz and Fanxin Long (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development.  Development 132, 49-60.

Matthew J. Hilton, Xiaolin Tu, Julie Cook, Hongliang Hu and Fanxin Long (2005). Ihh controls cartilage development by antagonizing Gli3 but requires additional effectors to regulate osteoblast and vascular development.  Development 132, 4339-51.

Fanxin Long*, Kyu-Sang Joeng, Shouhong Xuan, Argiris Efstratiadis, Andrew P. McMahon (2006).  Independent regulation of skeletal growth by Ihh and IGF signaling.  Dev. Biol. 298, 327-333.  *Corresponding author.

Xiaolin Tu, Kyu-Sang Joeng, Keiichi I. Nakayama, Keiko Nakayama, Jayaraj Rajagopal, Thomas J. Carroll, Andrew P. McMahon and Fanxin Long (2007).  Noncanonical Wnt signaling through G protein-linked PKCd activation promotes bone formation.  Dev. Cell 12, 113-27.  PMC1861818.

Matthew J. Hilton, Xiaolin Tu and Fanxin Long (2007).  Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.  Dev. Biol. 308, 93-105.  PMC2684901.

Matthew J. Hilton, Xiaolin Tu, Ximei Wu, Shuting Bai, Haibo Zhao, Tatsuya Kobayashi, Henry M. Kronenberg, Steven L. Teitelbaum, F. Patrick Ross, Raphael Kopan, Fanxin Long (2008).  Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.  Nat. Med. 14, 306-14.  PMC2740725.

Ximei Wu, Xiaolin Tu, Kyu Sang Joeng, Matthew J. Hilton, David A. Williams, Fanxin Long (2008). Rac1 activation controls nuclear localization of b-catenin during canonical Wnt signaling.  Cell 133, 340-53.  PMC2390926.

Kyu Sang Joeng and Fanxin Long (2009). The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.  Development 136, 4177-85, PMID: 19906844.

Kyu Sang Joeng, Cassie Schumacher, Cassie R. Zylstra-Diegel, Fanxin Long* and Bart O. Williams* (2011).  Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo.  Dev. Biol. 359, 222-9. PMID: 21924256.  * Corresponding authors.

Xiaolin Tu, Kyu Sang Joeng and Fanxin Long (2012).  Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev. Biol. 362, 76-82.  PMID: 21924256

Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler and Fanxin Long (2012).  Physiological Notch signaling maintains bone homeostasis via RBPjk and Hey upstream of Nfatc1. PLoS Genet. 2012 Mar;8(3):e1002577. doi: 10.1371/journal.pgen.1002577. Epub 2012 Mar 22.

Jianquan Chen and Fanxin Long (2012).  β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice.  J Bone Miner Res. 2012 Nov 27. doi: 10.1002/jbmr.1834. [Epub ahead of print]

Emel Esen, Jianquan Chen, Courtney M. Karner, Adewole L. Okunade, Bruce W. Patterson, Fanxin Long (2013).  WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.  Cell Metab. 2013 Apr 23. pii: S1550-4131(13)00141-1. doi: 10.1016/j.cmet.2013.03.017. [Epub ahead of print]

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Dr. Long’s Office Locations

BJC - Institute of Health

11th floor - RM 11613


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