Yousef Abu-Amer, PhD

Yousef Abu-Amer, PhD

Selected Publications
1. Zhang Y-H, Heulsmann A, Tondravi M, Mukherjee A, and Abu-Amer YTumor necrosis factor-alpha stimulates RANKL-induced osteoclast recruitment via coupling TNF receptor-1 and RANK signaling pathways.  J. Biol. Chem. 276(1):563-6568, 2001.

2. Abu-Amer Y.  Interleukin-4 abrogates osteoclastogenesis by mechanisms involving STAT6 inhibition of NF-kB transactivation.  J. Clin. Invest. 107(11):1375-1385, 2001.

3. Clohisy JC, Teitelbaum SL, CHen S, Erdmann J and Abu-Amer YTumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kB activation in osteoclast precursor cells.  J. Orthop. Res. 20:174-181,2002.

4. Clohisy JC, Frazier E, Hirayam T, and Abu-Amer YRANKL is an essential cytokine mediator of polymethylmethacrylate particle-induced osteoclastogenesis.  J. Orthop. Res. 21(2):202-212, 2003.

5. Abu-Amer Y.  Mechanisms of inflammatory mediators in bone loss diseases.  In: Rosier RN, Evans CH (eds): Molecular Biology in Orthopaedics, Rosemont IL, American Academy of Orthopaedic Surgeons, ppg. 229-239, 2003.

6. Abbas S, Clohisy JC, Abu-Amer YMitogen-activated protein kinases mediate PMMA-induction of osteoclasts.  J. Orthop. Res. 21:1041-1048, 2003.

7. Clohisy JC, Hirayama T, Frazier E, Han S, Abu-Amer YNF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis.  J. Orthop. Res. 22(1):13-20, 2004.

8. Clohisy JC, Biondo C, Roy B, Willis D,Teitelbaum SL, Abu-Amer YDirect inhibition of NF-kB blocks bone erosion associated with inflammatory arthritis.  J. Immunol. 171:5547-5553, 2003.

9. Abu-Amer Y, Abbas S, Hirayama T.  TNF receptor type-1 regulatres RANK ligand expression by stromal cells and modulates osteoclastogenesis.  J. Cell. Biochem., in press, 2004.

10. Dai S, Hirayama T, Abbas S, and Abu-Amer YThe IKK inhibitor, NEMO-binding domain peptide blocks osteoclastogenesis and bone erosion in inflammatory arthritis.  J. Biol. Chem. 272:37219-37222, 2004.

Make an Appointment

Dr. Abu-Amer’s Office Locations

BJC - Institute of Health

11th floor - RM 11614


The Department of Orthopaedic Surgery at Washington University School of Medicine in St. Louis has no control over third-party websites and does not review such websites. The university disclaims any responsibility for the content of third-party websites and the use of any information on these sites.